
Retatrutide
Retatrutide, nicknamed “GLP-3” online after its three receptor targets, is a synthetic triple-receptor agonist peptide synthesised as a GIP, GLP-1, and glucagon receptor agonist, studied in Eli Lilly Phase 2/3 metabolic research for its role in combined GIP, GLP-1, and glucagon receptor activation.
A triple agonist peptide targeting GIP, GLP-1, and glucagon receptors — studied in advanced metabolic and weight-regulation contexts.
For Research Use Only — Not for Human Consumption.
Investigational compound — no approved therapeutic indication.
Sold strictly for in vitro laboratory research.
- Availability
- Delivered in 3–7 days (EU)
- Storage
- Store 2–8 °C. Reconstitute before use.
- Ships from
- European fulfilment centre, tracked express
Lab proof, by batch
- Tested independently, by batch
- Certificate of analysis available
- Purity and identity on record
Up closeWeight / Metabolic Support
Retatrutide
Metabolic Systems
Triple Receptor Agonist Research.
Retatrutide (CAS 2381089-83-2) combines GIP, GLP-1, and glucagon receptor activation in a single sequence. Phase 2 clinical trials have reported substantial reductions in body weight and improvements in metabolic markers. Formula C223H341N57O64S, MW 4858.60 g/mol. Strict clinical guidance required.
- — Jastreboff et al. — Phase 2 trial of Retatrutide: dose-dependent weight-loss endpoints
- — Coskun et al. — GIP/GLP-1/glucagon tri-agonism and energy expenditure markers
Research context only. Not medical advice. Not for human or veterinary use.
- 10 mg lyophilised powder per vial
- Reconstitute with bacteriostatic water before use
- Store lyophilised at 2–8 °C, keep from light
- Once reconstituted, refrigerate and use within 28 days
- One 10 mg lyophilised Retatrutide vial
- Tamper-evident cap with batch-coded label
- Storage and clinician-consultation card
What the research reports about this molecule.
Classic parameters from peer-reviewed literature. Not human dosing guidance — read alongside the PubMed references on /learn.
- Sequence
- Triple GIP/GLP-1/glucagon receptor agonist
- Mechanism
- Activates GIP, GLP-1, and glucagon receptors
- Research domain
- Metabolic, weight regulation (Eli Lilly Phase 2/3)
- Reconstitution
- Bacteriostatic water, USP
- Storage
- Long-term -20°C lyophilised; -80°C for >12 months; reconstituted 2-8°C, ≤4 weeks
From arrival to storage.
Laboratory handling notes for this compound. Peptyds products are supplied for research use only, not for human or veterinary use, so we give no dosing or administration guidance.
- 1
Store the sealed vial at 2–8 °C, away from light
- 2
Reconstitute with bacteriostatic water — swirl, do not shake
- 3
Label the vial with its batch number and reconstitution date
- 4
Refrigerate reconstituted vial; use within 28 days
Handling guide
Read the reconstitution guide
Reconstitution and storage for laboratory handling, step by step.
Reconstitution calculator
Research use onlySyringe
Peptide in vial
Bacteriostatic water
Concentration5 mg/mL
Target dose
Pull syringe to
5
units · 0.05 mL
Concentration
5
mg/mL
Doses per vial
40
doses
U-50 2.5 · U-40 2 units
For laboratory research calculation only. Not medical or dosing advice, and not for human or veterinary use.
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Each release is matched with quality documentation through a documented verification path. Identity, purity, and composition test results sit on the product page before you buy.
Every batch is verified by an ISO/IEC 17025-accredited laboratory before release. Identity, purity, and documentation travel with the product — not behind a form.
Sensitive peptides ship in insulated cold packaging with gel packs sized for a 48-hour transit window, tracked door to door.
Everything worth asking before you order.
Shipping, storage, quality, and when to speak to a clinician — without the runaround.
What proof of quality comes with my order?
Every batch ships with a batch code printed on the vial. The matching independent lab report — showing identity, purity, and composition — is linked on the product page and stays on your order page after purchase.
Should I speak to a clinician before using a peptide?
We recommend it — especially if you are pregnant, nursing, managing a medical condition, or combining peptides with prescribed medication. Our product pages are educational. They are not medical advice and they do not replace a conversation with a qualified practitioner.
When will my order ship and arrive?
Orders placed before 14:00 CET Monday–Friday ship the same business day from our European fulfilment centre in The Hague, Netherlands. Standard tracked EU delivery arrives in 2–4 business days; express options are available at checkout.
What does "research only" actually mean on a peptide label?
Research-only means the compound has not been approved by the EMA or any national medicines authority for medical use, and is sold solely for in-vitro and laboratory research. It is not a supplement, a cosmetic, or a medicine, and it carries no claims for human consumption.
Is retatrutide approved or available as a medicine?
No. Retatrutide is a triple agonist of GLP-1, GIP, and glucagon receptors developed by Eli Lilly and currently in Phase 3 trials (TRIUMPH programme). It is not approved by the EMA or FDA, so it cannot be prescribed. Phase 2 data showed up to ~24 percent body-weight reduction at 48 weeks.
What are the most common side effects of GLP-1 peptides specifically?
Across SUSTAIN, SURPASS, SURMOUNT, and TRIUMPH trials, the dominant adverse events for semaglutide, tirzepatide, and retatrutide are gastrointestinal: nausea, vomiting, diarrhoea, constipation, and abdominal discomfort, usually mild-to-moderate and concentrated during dose titration.
What's the difference between a prescription peptide and a research peptide?
A prescription peptide (e.g. Wegovy, Mounjaro, Vyleesi, Zadaxin in the relevant jurisdictions) has been through EMA or national-authority review, carries an authorised indication, and is dispensed by a pharmacy against a script. A research peptide is a reference-grade compound sold for laboratory use only.
How do I reconstitute a lyophilised peptide vial?
Bring both the lyophilised vial and the bacteriostatic water to room temperature, equalise pressure with a sterile vented needle, then inject the solvent slowly down the side of the vial. Swirl gently — never shake — until clear, and refrigerate at 2–8 °C.
How much bacteriostatic water should I add to my peptide vial?
The calculation is peptide mass (mg) ÷ desired concentration (mg/mL) = volume of bacteriostatic water in mL. For example, a 5 mg vial at 1 mg/mL needs 5 mL; at 2 mg/mL, 2.5 mL. Every Peptyds product page carries a suggested reconstitution volume tuned to the vial size.
How long does a reconstituted peptide stay stable in the fridge?
Most lyophilised peptides reconstituted with bacteriostatic water remain stable for 28–30 days at 2–8 °C, protected from light. A handful of short, fragile sequences — Epithalon among them — drop to roughly 14 days. Never freeze a reconstituted vial.
What side effects are most commonly reported across peptide research?
Across published trials and case series, the most frequent reported events are injection-site reactions (redness, induration, transient discomfort), headache, mild nausea, and temporary fatigue. GLP-1 and dual-agonist class peptides add dose-dependent gastrointestinal effects.
Who should not use peptides?
Peptides are not appropriate for anyone who is pregnant, nursing, planning conception, under 18, managing active cancer, or on immunosuppressants — and competitive athletes governed by WADA must avoid every peptide on the prohibited list. Anyone with a personal or family history of melanoma should specifically avoid melanocortin-receptor agonists.



